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Oxford, UK 14 November 2012: Oxford BioMedica (“Oxford BioMedica” or “the Company”) (LSE: Oxford Biomedica), the leading gene-based biopharmaceutical company, today publishes its interim management statement for the period from 1 July to 13 November 2012.
OPERATIONAL HIGHLIGHTS
LentiVector® platform
Ocular programmes (gene-based therapies targeting vision loss): partnered with Sanofi
- RetinoStat® and StarGen™ clinical studies received positive review by Data Safety Monitoring Board
- Second RetinoStat® clinical site initiated at the Oregon Health and Science University, Portland (USA)
- Final RetinoStat® patient cohort recruiting across two clinical sites (n=9, confirmatory dose level)
- UshStat® clinical study received funding award of US$125,000 from the Foundation Fighting Blindness
Manufacturing, alliances and intellectual property (IP): continued commercial focus
- Successful launch of a new online portal – Oxford Biomedica Solutions – to showcase leading viral vector GMP manufacturing competences: www.oxbsolutions.co.uk
- New collaboration with Immune Design Corp. to leverage expertise in lentiviral vector clinical development
- Leading IP position strengthened by key US patent relating to the delivery of RNAi using lentiviral vectors
5T4 tumour antigen platform
TroVax® (therapeutic cancer vaccine): investigator-led Phase II programme underway
- First patient treated in Phase II study for TroVax® in colorectal cancer led by Cardiff University, Wales (UK)
- Initial data trends from US Phase II trial in hormone refractory prostate cancer (HRPC) indicate that the Company’s pre-treatment biomarker can identify patients most likely to benefit from treatment with TroVax®
- Strategic decision to close the US Phase II HRPC trial and focus on collaborative Phase II studies
Targeted antibody therapy for cancer: partnered with Pfizer
Further presentations of the 5T4 antibody drug conjugate (ADC) programme at key industry conferences:
- Antibody-Drug Conjugates, Bispecifics & Empowered Antibodies Summit in August 2012
- The International Society for the Study of Xenobiotics in October 2012
FINANCIAL REVIEW
The Company’s net cash1 balance at 30 June 2012, as stated in the interim report, was £6.6 million (unaudited). The cash position has since been strengthened by £10.1 million net proceeds from a fundraising which completed in July 2012, in addition to a total £1.9 million option exercise payment from Sanofi for StarGen™ and UshStat®. At 31 October 2012, the Company had a net cash1 balance of £14.4 million (unaudited).
1. Cash, cash equivalents and available for sale investments
OUTLOOK
Oxford BioMedica remains focused on delivering the objectives set across its core ophthalmology portfolio, further developing its manufacturing capabilities and securing new industry alliances for its high-value products and intellectual property.
John Dawson, Chief Executive Officer of Oxford BioMedica, said: “The commercial prospects for our pioneering technologies continue to improve. Our priority remains to secure a strong future for the Company and, as we continue to deliver operational progress, we are increasingly well-placed to build a financially self-sustaining business via organic growth, new alliances and strategic corporate activity.”
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