>340
GMP batches released
>50
Audits completed
>30
Process development projects
>70
Qualified assays and methods
About Oxford Biomedica
We believe in pushing the boundaries of scientific possibility and know it takes exceptional knowledge and innovative processes to make that happen.
- 1st worldwide to administer lentiviral vector gene therapy in vivo
- 1st commercial supplier of lentiviral vectors for a CAR-T therapy
inAAVate™ platform
Bring confidence to clinical trials with our proven AAV viral vector development and production process, capable of producing consistently high quality and high titre products.
We have:
- Demonstrated >E15 vg/L titers
- Achieved >90% fully intact vector
- Analytical toolbox with over 45 methods
- Process scales from 2L to 2000L
- Six successful IND/CTA filings
Tech transferred-in
Alongside our own LentiVector® and AAV platform technologies, we have the facilities and expertise to fulfil almost any development need. You define the methods and processes, and we leverage our class-leading capabilities as appropriate.
Latest news
Discover our latest updates.
Oxford Biomedica Appoints Laurence Espinasse as Non-Executive Director
Oxford, UK – 25 July 2024: Oxford Biomedica plc (LSE:OXB) (“Oxford Biomedica”, “OXB” or “the Company”), a quality and innovation-led cell and gene therapy CDMO, today announces the appointment of Laurence Espinasse as a Non-Executive Director, effective as of 24 July 2024. Ms. Espinasse brings more than two decades of experience across the legal and healthcare sectors and since 2021 has served as the General Counsel and Compliance Officer at Institut Mérieux SA (“Institut Mérieux”). Following the acquisition of ABL Europe (since renamed Oxford Biomedica (France)) in January 2024, Institut Mérieux is now a major shareholder in Oxford Biomedica, owning more than 10 percent of the Company’s ordinary shares. Prior to her current role at Institut Mérieux, Ms. Espinasse was a Partner and Head of the Business Law Department at MDL Société d’Avocats. Before that, she practiced business law at EY. She obtained her professional lawyer’s certificate from the École des Avocats Centre Sud in Montpellier, France. Dr. Roch Doliveux, Chair of Oxford Biomedica, commented: “On behalf of the Board, I am delighted to welcome Laurence Espinasse as Non-Executive Director. Her vast legal experience will be a strong asset for the Company as we look to build on significant commercial momentum and capitalise on the fast-growing cell and gene therapy sector. We look forward to her support and advice in driving OXB’s continued success.” Laurence Espinasse, incoming Board Member at Oxford Biomedica, added: “Following the acquisition of ABL Europe, I am honoured to be joining Oxford Biomedica’s Board of Directors. Institut Mérieux’s significant investment reflects our confidence in Oxford Biomedica’s potential. I look forward to working closely with the Board to drive the next phase of growth as a world-leading cell and gene therapy CDMO.” Relevant disclosures Ms. Espinasse previously served as a director at Transgene SA, from May 2022 to May 2023. There are no additional disclosures required to be made in accordance with LR 9.6.13R. Enquiries: Oxford Biomedica plc: Sophia Bolhassan, Head of Investor Relations – T: +44 (0) 1865 509 737 / E: ir@oxb.com ICR Consilium: T: +44 (0)20 3709 5700 / E: oxfordbiomedica@icrhealthcare.com Mary-Jane Elliott / Angela Gray / Davide Salvi About Oxford Biomedica Oxford Biomedica (LSE: OXB) is a quality and innovation-led contract development and manufacturing organisation (CDMO) in cell and gene therapy with a mission to enable its clients to deliver life changing therapies to patients around the world. One of the original pioneers in cell and gene therapy, OXB has more than 25 years of experience in viral vectors; the driving force behind the majority of cell and gene therapies. OXB collaborates with some of the world’s most innovative pharmaceutical and biotechnology companies, providing viral vector development and manufacturing expertise in lentivirus, adeno-associated virus (AAV), adenovirus, and other viral vector types. Oxford Biomedica’s world-class capabilities span from early-stage development to commercialisation. These capabilities are supported by robust quality-assurance systems, analytical methods and depth of regulatory expertise. Oxford Biomedica, a FTSE4Good constituent, is headquartered in Oxford, UK. It has bioprocessing and manufacturing facilities across Oxfordshire, UK, Lyon and Strasbourg, France, and near Boston, MA, US. Learn more at www.oxb.com, and follow us on LinkedIn and YouTube.
Read moreOxford Biomedica announces Chief Financial Officer transition
Oxford, UK – 17 July 2024: Oxford Biomedica plc (LSE:OXB) (“Oxford Biomedica”, “OXB” or “the Company”), a quality and innovation-led cell and gene therapy CDMO, today announces the appointment of Lucinda (Lucy) Crabtree Ph.D. as Chief Financial Officer (CFO) and Board member. Simultaneously, the Company announces that Stuart Paynter will step down as CFO and from the Board after almost seven years of service. These changes will become effective on 2 September 2024 and Stuart will then transition away from Oxford Biomedica following a suitable handover period. Lucinda Crabtree was previously CFO at MorphoSys AG. As CFO of MorphoSys, Lucy led a finance team across the US and Germany until the closing of the acquisition of the company by Novartis. Prior to MorphoSys, Lucy was CFO at Autolus Therapeutics, a Nasdaq listed clinical stage biopharmaceutical company. Before her time at Autolus, Lucy spent several years as an investment professional at institutions including Woodford Investment Management, Panmure Gordon, Goldman Sachs, J.P. Morgan (originally Bear Stearns) and Jefferies. Lucy also has prior experience as a board observer at several private healthcare companies. She holds a first class Bachelor of Science degree in Physiology and Pharmacology from University College London and a Ph.D. in Pharmacology from University College London. Dr. Frank Mathias, Chief Executive Officer of Oxford Biomedica, commented: “On behalf of the corporate executive team, I am delighted to welcome Lucy to Oxford Biomedica. Her unique skillset will be immensely valuable to us as we enter the next phase of our growth as a pure-play CDMO. I would also like to warmly thank Stuart for his dedicated service to OXB. Since joining the Company nearly seven years ago, Stuart has been instrumental in its success right the way through to the recent transformation of our business model. We wish him all the best for his future endeavours.” Stuart Paynter said: “It has been a pleasure and a privilege to help lead Oxford Biomedica through its development to its position as a leading CDMO. The Company is now operationally and financially in stronger health than ever before and, with the transformation complete, it is now the natural time to hand over to someone with Lucy’s skills and experience. I look forward to continuing to support OXB in the interim and then as it enjoys further success and momentum in the future.” Lucinda Crabtree said: “This is an exciting time to join Oxford Biomedica, having entered a new phase as an international pure-play cell and gene therapy CDMO. I look forward to working with Frank and the senior leadership team alongside the Board, as we continue to execute on this integrated strategy and continue our growth in the backdrop of a rapidly expanding cell and gene therapy market.” Relevant disclosures: There are no disclosures required to be made in accordance with LR 9.6.13R. Enquiries: Oxford Biomedica plc: Sophia Bolhassan, VP, Corporate Affairs and IR – T: +44 (0) 1865 509 737 / E: ir@oxb.com ICR Consilium: T: +44 (0)20 3709 5700 / E: oxfordbiomedica@consilium-comms.com Mary-Jane Elliott / Angela Gray / Davide Salvi About Oxford Biomedica Oxford Biomedica (LSE: OXB) is a quality and innovation-led contract development and manufacturing organisation (CDMO) in cell and gene therapy with a mission to enable its clients to deliver life changing therapies to patients around the world. One of the original pioneers in cell and gene therapy, OXB has more than 25 years of experience in viral vectors; the driving force behind the majority of cell and gene therapies. OXB collaborates with some of the world’s most innovative pharmaceutical and biotechnology companies, providing viral vector development and manufacturing expertise in lentivirus, adeno-associated virus (AAV), adenovirus, and other viral vector types. Oxford Biomedica’s world-class capabilities span from early-stage development to commercialisation. These capabilities are supported by robust quality-assurance systems, analytical methods and depth of regulatory expertise. Oxford Biomedica, a FTSE4Good constituent, is headquartered in Oxford, UK. It has bioprocessing and manufacturing facilities across Oxfordshire, UK, Lyon and Strasbourg, France, and near Boston, MA, US. Learn more at www.oxb.com, and follow us on LinkedIn and YouTube.
Read morePreliminary results for the year ended 31 December 2023
Oxford, UK – 29 April 2024: One OXB: Building a pure-play cell and gene therapy CDMO; existing financial guidance affirmed • Chief Executive Officer Dr. Frank Mathias, one year into his role, is successfully leading the transformation of OXB into a global, pure-play, quality and innovation-led cell and gene therapy CDMO • “One OXB” strategy well underway, optimising operations across the UK, US and EU with a streamlined workforce and site-based model • Over 50% growth in both orders and pipeline in 2023: An increase of 54% in contracted value of client orders signed; grew from £85 million in 2022 (excluding COVID-19 vaccine manufacturing) to £131 million in 2023 An increase of 51% in the business development pipeline; from $291 million to $438 million from January to December 2023 • Significant commercial momentum with strong demand for OXB’s CDMO services across all key viral vector types, with an expanded client portfolio including 35 clients and 51 programmes as of April 2024 (April 2023: 18 clients and 34 programmes), now includes new clients gained through Oxford Biomedica (France) • Acquisition of ABL Europe (recently renamed Oxford Biomedica (France)) from Institut Mérieux, completed post-period end, enhances OXB’s bioprocessing and manufacturing footprint in the EU, strengthening the Group’s multi-vector, multi-site model spanning the UK, US and the EU • Reiterates its existing financial guidance communicated to the market • Briefing and webcast for analysts to be held today at 13:00 BST / 08:00 ET – see details below Oxford, UK – 29 April 2024: Oxford Biomedica plc (“Oxford Biomedica” or “the Group”) (LSE: OXB), a quality and innovation-led cell and gene therapy CDMO, today announces its preliminary results for the year ended 31 December 2023. Dr. Frank Mathias, Oxford Biomedica’s Chief Executive Officer, said: “2023 was a year of transformation for Oxford Biomedica. We are building our position as a global pure-play cell and gene therapy CDMO and through our ‘One OXB’ strategy are unifying our operations in the UK, US and the EU, including our newly-acquired sites in France. I am delighted with the positive outcomes of our strategy, which have already resulted in a substantial increase in contracted client orders and our business development pipeline. Despite challenging market conditions, we continue to see strong demand for our CDMO services, further solidifying our position as a world-leading global CDMO in the rapidly expanding cell and gene therapy market. Our focus in 2024 remains on growing our global portfolio of clients and projects across all stages of clinical development whilst completing the integration of our sites. This integration will allow us to better align to the demands of performing as a pure-play CDMO. With a highly experienced Corporate Executive Team and a focus on delivering high-quality CDMO services to our clients, our realigned business is well-positioned to help our clients deliver their transformative treatments to patients and drive long-term sustainable growth for the Group. “I would also like to take this opportunity to express my gratitude to all our employees for their tireless efforts, as well as their perseverance and commitment during a period of significant change for the Group. Their dedication and hard work have been instrumental in our transformation into a pure-play CDMO and achieving the significant milestones along the way.” FINANCIAL HIGHLIGHTS (including post-period events) • Stable core business revenues: Small increase in core business revenues whilst total revenues decreased by 36% to £89.5 million (2022: £140.0 million) due to the non-recurrence of vaccine manufacturing revenues • Rebased business with streamlined cost base Operating EBITDA1 loss of £(52.8) million (2022: £1.6 million) Operating loss of £(184.2) million (2022: £(30.2) million) included £99.3 million impairment charge to the US business driven by the cessation of revenues from Homology Completed c.£30 million reduction in ongoing cost base (on an annualised basis compared to 2023) Due to the decision by Homology to cease clinical activities, the Group performed an impairment assessment of OXB (US) LLC, resulting in an impairment of £99.3 million (2022: £nil). • Balance sheet sufficient to achieve strategic objectives Cash of £103.7 million at 31 December 2023 (2022: £141.3 million); Net cash at 31 December 2023 was £65.2 million (2022: £101.5 million) • Commercial KPIs give confidence in future growth Contracted value of client orders signed in the year ended 31 December 2023 was £131 million, an increase of over 50% compared to £85 million in 2022 Revenue backlog2(including France) at 31 March 2024 stood at £104 million, a growth of 11% from £94 million at 31 December 2023 (excludes order from recently signed commercial agreement); this is the amount of future revenue available to earn from current orders OUTLOOK AND FINANCIAL GUIDANCE • The Group reiterates its existing near term and medium-term financial guidance communicated to the market: 2024 total Group revenues of between £126 million and £134 million, with a three-year revenue CAGR of more than 35% for 2023-2026 Broadly breakeven EBITDA in 2024, excluding the impact of the acquisition of ABL Europe (recently renamed Oxford Biomedica (France)) A modest operating loss in 2024 is expected due to the recently acquired sites in France, which will be fully funded by the €10 million cash funding in ABL Europe (recently renamed Oxford Biomedica (France)) from Institut Mérieux as part of the acquisition The Group expects to achieve Operating EBITDA margins in excess of 20% by the end of 2026, and to be profitable on an EBITDA level in 2025. 1. Operating EBITDA (Earnings Before Interest, Tax, Depreciation, Amortisation, Impairment, revaluation of investments and assets at fair value through profit and loss, and Share Based Payments) is a non-GAAP measure often used as a surrogate for operational cash flow as it excludes from operating profit or loss all non-cash items, including the charge for share based payments. However, deferred bonus share option charges are not added back to operating profits in the determination of Operating EBITDA as they may be paid in cash upon the instruction of the Remuneration Committee. A reconciliation to GAAP measures is provided on page 17. 2. Revenue backlog represents ordered CDMO revenues available to earn. The value of customer orders included in revenue backlog only includes the value of work for which the customer has signed a financial commitment for OXB to undertake, whereby any changes to agreed values will be subject to either change orders or cancellation fees. ANALYST BRIEFING Oxford Biomedica’s management team, led by CEO, Dr. Frank Mathias, CFO, Stuart Paynter, CCO, Dr. Sebastien Ribault and COO, Thierry Cournez, will be hosting a briefing and Q&A session for analysts at 13:00 BST / 8:00 EST today, 29 April, at One Moorgate Place Chartered Accountants Hall, 1 Moorgate Pl, London EC2R 6EA, United Kingdom. A live webcast of the presentation will be available via this link. The presentation will be available on Oxford Biomedica’s website at www.oxb.com If you would like to dial in to the call and ask a question during the live Q&A, please email Oxfordbiomedica@consilium-comms.com ______________ Read the OXFORD BIOMEDICA PLC Preliminary results for the year ended 31 December 2023 in full: Download PDF here Notes Unless otherwise defined, terms used in this announcement shall have the same meaning as those used in the Annual report and accounts. ENQUIRIES Oxford Biomedica plc: Sophia Bolhassan, VP, Corporate Affairs and IR T: +44 (0)1865 783 000 / E: ir@oxb.com ICR Consilium: Mary-Jane Elliott / Angela Gray / Davide Salvi, T: +44 (0)20 3709 5700 RBC Capital Markets (Joint Corporate Brokers): Rupert Walford /Kathryn Deegan, T: +44 (0)20 7653 4000 J.P. Morgan Cazenove (Joint Corporate Brokers): James Mitford / Manita Shinh / Jem de los Santos, T: +44 (0)20 7134 7329 ABOUT OXFORD BIOMEDICA Oxford Biomedica (LSE: OXB) is a quality and innovation-led cell and gene therapy CDMO with a mission to enable its clients to deliver life changing therapies to patients around the world. One of the original pioneers in cell and gene therapy, the Company has more than 25 years of experience in viral vectors; the driving force behind the majority of gene therapies. The Company collaborates with some of the world’s most innovative pharmaceutical and biotechnology companies, providing viral vector development and manufacturing expertise in lentivirus, adeno-associated virus (AAV), adenoviral vectors, and other viral vector types. Oxford Biomedica’s world-class capabilities span from early-stage development to commercialisation. These capabilities are supported by robust quality-assurance systems, analytical methods and depth of regulatory expertise. Oxford Biomedica, a FTSE4Good constituent, is headquartered in Oxford, UK. It has bioprocessing and manufacturing facilities across Oxfordshire, UK, Lyon and Strasbourg, France, and near Boston, MA, US. Learn more at www.oxb.com, and follow us on LinkedIn and YouTube.
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Learn about our 4th generation lentiviral vector delivery system and how this latest lentiviral vector technology developed at Oxford Biomedica can significantly enhance the development and manufacture of safer and more effective lentiviral vector based.
You can also download brochures for our other unique technologies including our TRiP System™ and LentiStable™ cell lines here.
