Resources library
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Addressing AAV Manufacturing Challenges
This brochure demonstrates how OXB addresses AAV manufacturing challenges with robust upstream, downstream, analyics and regulatory services.
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Enhanced Transcriptional Insulation of Lentiviral Vectors using “Sequence Upgraded polyA Long Terminal Repeats” or “supA-LTRs”
SupA-LTR technology enhances lentiviral vector safety and performance by reducing transcriptional read-through, improving polyadenylation, and increasing transgene expression.
View PDF >Improved Production and Quality of Lentiviral Vectors by Major-Splice-Donor Mutation and Co-expression of a Novel U1 snRNA-based Enhancer
Discover how the TetraVecta™ system eliminates aberrant vector RNA splicing, enhances TRiP system™ performance, and improves the safety and utility of next-generation gene therapy vectors.
View PDF >On-the-Fly Optimization of Anion-Exchange Chromatography for High-Purity AAV Separation
This poster is about OXB’s inAAVate™ platform for rapidly developing anion-exchange chromatography (AEX)-based purification processes that efficiently separate full and empty AAV capsids, achieving up to 90% full capsid purity while enabling faster, scalable gene therapy manufacturing workflows.
View PDF >Beyond the Buzzword: What ‘Commercial-Ready’ Really Means in Cell and Gene Therapy
This presentation defines what “commercial-ready” means in cell and gene therapy based on OXB’s CDMO experience. It outlines the key operational, regulatory, and manufacturing requirements needed for commercial success, and discusses how to achieve commercial readiness while improving cost efficiency.
View PDF >Beyond 90% Full: Expanding the Role of Anion Exchange Chromatography in AAV Product Quality Control
This presentation introduces OXB’s AAV platform and its anion exchange chromatography (AEX) development toolkit, highlighting how rapid AEX development is performed during feasibility studies. It also explores the broader role of AEX in impurity removal, extending beyond empty capsid clearance to improve overall product quality.
View PDF >Automation of Cell Based Assays: QC Implementation Strategies and Challenges
This presentation explores best practices for implementing automated platforms in QC environments, including strategies to address key challenges such as validation, data integrity, and change management. It also highlights the impact of automation on improving assay robustness and supporting regulatory compliance.
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