Resources library
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AAV: Addressing AAV Manufacturing Challenges
This brochure demonstrates how OXB addresses AAV manufacturing challenges with robust upstream, downstream, analyics and regulatory services.
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On-the-Fly Optimization of Anion-Exchange Chromatography for High-Purity AAV Separation
This poster is about OXB’s inAAVate™ platform for rapidly developing anion-exchange chromatography (AEX)-based purification processes that efficiently separate full and empty AAV capsids, achieving up to 90% full capsid purity while enabling faster, scalable gene therapy manufacturing workflows.
View PDF >Beyond the Buzzword: What ‘Commercial-Ready’ Really Means in Cell and Gene Therapy
This presentation defines what “commercial-ready” means in cell and gene therapy based on OXB’s CDMO experience. It outlines the key operational, regulatory, and manufacturing requirements needed for commercial success, and discusses how to achieve commercial readiness while improving cost efficiency.
View PDF >Just Because You Can, Doesn’t Mean You Should: Why Higher Upstream Titer May Not Be Best for Your AAV Process
This presentation explores why OXB changed its upstream platform despite resulting in lower titers, and how intentionally sacrificing titer can sometimes improve overall product quality. It also examines the titers achievable through upstream process and plasmid optimization, and evaluates whether pursuing higher titers is ultimately worthwhile.
View PDF >Beyond 90% Full: Expanding the Role of Anion Exchange Chromatography in AAV Product Quality Control
This presentation introduces OXB’s AAV platform and its anion exchange chromatography (AEX) development toolkit, highlighting how rapid AEX development is performed during feasibility studies. It also explores the broader role of AEX in impurity removal, extending beyond empty capsid clearance to improve overall product quality.
View PDF >Automation of Cell Based Assays: QC Implementation Strategies and Challenges
This presentation explores best practices for implementing automated platforms in QC environments, including strategies to address key challenges such as validation, data integrity, and change management. It also highlights the impact of automation on improving assay robustness and supporting regulatory compliance.
View PDF >Justifying a Pathway to Reduced Replication-Competent Lentivirus (RCL) Testing: Adding the Empirical to the Theoretical
This presentation focuses on the topic of replication-competent lentiviruses (RCLs), explaining why they have not been observed to date and introducing frameworks for distinguishing between possible and plausible RCL risk. It also outlines future strategies aimed at optimizing and potentially reducing RCL testing requirements.
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